Secondary hyperparathyroidism is a disease of the parathyroid glands that was caused by some other disease. The parathyroid glands grew big and went crazy "secondary" to some other problem.

caused by something else
condition of too much parathyroid gland activity
hyper = too much
parathyroid = parathyroid gland
ism = a disease or condition

Secondary Hyperparathyroidism is rare, except in certain scenarios.

Primary Hyperparathyroidism is common!

Secondary Hyperparathyroidism causes and diagnosis. Low vitamin D.

IMPORTANT!  Most cases of hyperparathyroidism are PRIMARY hyperparathyroidism, which is what most of this huge website is about. You should NOT read this page if your doctor did not mention secondary hyperparathyroidism. You should read this if you have kidney problems, and you must read this if your doctor said you have high parathyroid hormone and secondary hyperparathyroidism because you are developing kidney failure! You will learn that unless you are having kidney dialysis every other day because you don't have any kidneys, then it is almost guaranteed you do not have secondary hyperparathyroidism. This is the only page of this very large website on secondary hyperparathyroidism.

OK, Here we go: Secondary Hyperparathyroidism:

Secondary hyperparathyroidism means the parathyroid glands are overproducing parathyroid hormone in an attempt to help the body increase the amount of calcium in the blood. It is the only job of the parathyroid glands to maintain normal calcium levels and the four parathyroid glands will increase the production of their hormone (parathyroid hormone PTH) if the calcium is too low. When a person has secondary hyperparathyroidism, then something is causing the parathyroid glands to become over active, thus we say it is 'secondary' (caused by) something else. Secondary hyperparathyroidism cannot ever be associated with high blood calcium. Even a slightly high calcium level excludes the possibility of secondary hyperparathyroidism. Thus if your calcium level is 10.0 mg/dl or higher (2.5 mmol/l or higher for our European friends) you cannot have secondary hyperparathyroidism.

Secondary hyperparathyroidism only occurs in a few situations where a patient cannot absorb enough calcium in their diet, or they have kidney failure requiring dialysis and they lose control of calcium and phosphorus. Because it is the primary and only job of the parathyroid glands to help maintain calcium in the normal range, a low calcium level will cause all four parathyroid glands to produce more parathyroid hormone (PTH) in an attempt to increase calcium absorption in the intestines, and to remove calcium out of the bones. The net effect is that the parathyroid glands will increase the amount of calcium in the blood by taking it out of the bones-but this can only happen if the blood calcium is low to start with. Thus the parathyroid glands are overworking 'secondary' to (because of) a low blood calcium level. If you have a high normal, or high calcium level, you cannot develop secondary hyperparathyroidism.

Causes of Secondary Hyperparathyroidism

There are only a few causes of secondary hyperparathyroidism. All of them are associated with poor absorption of calcium by the intestines, leading to low normal or low blood calcium. If you don't have one of these situations, then you cannot have secondary hyperparathyroidism. Remember, the parathyroid glands are unhappy and going crazy because the calcium is low (or phosphorus is high--more about that later).

Causes of Secondary Hyperparathyroidism

  • Kidney failure requiring dialysis (GFR less than 15)
    • If you are not on dialysis, it is almost impossible to have secondary hyperparathyroidism
  • Stomach or intestine bypass for obesity surgery
    • Gastric Stapling
    • Roux-n-Y Bypass
    • Gastric (stomach) Bypass
  • Celiac Disease (typically severe for many years)
  • Crohn's Disease (typically severe for many years)
  • Severe vitamin D deficiency
    • Must have low blood calcium levels-cannot lead to high blood calcium
    • Note: Primary hyperparathyroidism also causes low Vitamin D, so if your Vitamin D is low but your calcium is high, you have a parathyroid tumor.
    • This is the most common mistake in all of medicine. Low vitamin D does NOT cause high blood calcium. If your doctor said you have secondary hyperparathyroidism because your vitamin D is low, then check your calcium. If your calcium is high, then you have primary hyperparathyroidism, not secondary.

Confusion of Primary vs. Secondary Hyperparathyroidism

The biggest mistake made by all types of doctors, including nephrologists and endocrinologists is to confuse primary hyperparathyroidism with secondary hyperparathyroidism. This is VERY important since primary hyperparathyroidism must be cured with surgery while secondary hyperparathyroidism is treated with vitamin D (and calcium). Think of these two as opposites! If you simply remember that secondary hyperparathyroidism cannot ever be associated with high blood calcium, then you will get this correct almost all the time. If it is so simple, then why do doctors get this wrong all the time? We wish we could tell you that answer, but this mistake is the reason we made the Vitamin-D-Pro app'so people could tell primary hyperparathyroidism from secondary hyperparathyroidism. This is why the app asks questions about stomach surgery, kidney stones and dialysis on the front page. Vitamin D can have great benefits for many people, but must be avoided in people with high blood calcium (primary hyperparathyroidism).

Primary hyperparathyroidism is caused by a tumor of a parathyroid gland. This leads to high blood calcium in almost all cases. Primary hyperparathyroidism is treated with surgery to remove the parathyroid tumor from the neck. Primary hyperparathyroidism CANNOT be treated with vitamin D. In fact, giving vitamin D to a patient with high blood calcium can be dangerous and can cause the blood calcium to rise to very high levels and even cause heart attacks and stroke. Primary hyperparathyroidism is discussed in detail in other articles, but you can remember the difference because primary hyperparathyroidism is 'primarily a parathyroid problem'. There is nothing else that caused the parathyroid glands to become active. The person developed a tumor on a parathyroid gland (in their neck).

Secondary hyperparathyroidism is NOT caused by a parathyroid tumor. Secondary hyperparathyroidism is treated with high doses of vitamin D, often including high doses of calcium (depending on the situation).

Why do Doctors Confuse Primary Hyperparathyroidism as Secondary?

Careful here folks... we are about to confuse you. Primary hyperparathyroidism is almost always associated with low vitamin D. About 92% of our last 23,000 patients being operated on for primary hyperparathyroidism (and having a parathyroid tumor removed from their neck) had low vitamin D (less than 30 ng/ml in the U.S. and less than 80 nmol/L in most other countries) (different units of measure).

It is the low vitamin D that confuses doctors. They all make the assumption that the low vitamin D is the problem, and therefore jump immediately to the conclusion that the patient has secondary hyperparathyroidism.>Since low vitamin D is common, and giving vitamin D is a good thing, they just assume the patient has low vitamin D and this has somehow caused a problem with the parathyroid glands that has lead to high blood calcium.  This cannot happen. There is no mechanism by which a low vitamin D level can lead to high blood calcium. Vitamin D is required for calcium absorption in the intestines, and therefore, you cannot, under any circumstance have high blood calcium because of the low vitamin D. If your calcium is high (even slightly high) and your vitamin D is low, then the excess calcium in the blood must have come from somewhere other than the intestines and your diet. The only other source of calcium is your bones and that is the primary action of parathyroid hormone.

Thus, if the calcium is high and the vitamin D is low, the patient is almost guaranteed to have primary hyperparathyroidism and a parathyroid tumor in their neck. The body has turned off vitamin D production because the body doesn't want more calcium. There is too much calcium in the blood already and thus the body does not want to absorb any more calcium from the intestines'so it turns off the vitamin D, and vitamin D levels fall. Almost all patients with a parathyroid tumor have low vitamin D.  It is inappropriate to give vitamin D to a patient with high blood calcium. If the user of this app has calcium levels above 10.1 mg/dl (2.6 mmol/L) then it will not make recommendations for them in the vitamin store, and will tell them that taking vitamin D can be dangerous.

Remember, you cannot have secondary hyperparathyroidism and have high blood calcium. Secondary hyperparathyroidism can ONLY be seen with calcium levels that are mid-normal, low normal, or low.

Kidney Disease and Increasing Parathyroid Hormone Levels

Parathyroid Hormone in Kidney Failure accourding to GFR. Secondary hyperparathyroidism occurs in all (yes, all) patients who have kidney failure, HOWEVER, they must have such severe kidney failure that they are on dialysis. This is another amazingly common mistake made by almost all nephrologists. Yes, it is true, at least 90% of kidney doctors can't tell the difference between primary and secondary hyperparathyroidism. This graph shows kidney function on the bottom "X" axis with the green areas being great kidney function where the kidney can filter over 90 ml of blood every minute (called GFR, meaning glomerular filtration rate). As the kidneys fail, they filter (clean) less of the blood, so that a kidney that can only filter between 30 and 60 ml per minute (about a coffee cup full) are said to have Stage III kidney failure. The vertical "Y" axis shows parathyroid hormone levels. This graph shows that parathyroid hormone (PTH) levels (a measure of the activity of the parathyroid glands) remains normal (between 15 and 65 pg/ml) until patients have a GFR less than 15. The blue dots are PTH levels in 300 patients with worsening kidney failure showing that the PTH does not rise until the GFR is less than 20, or really, less than 15. And, it needs to be less than 15 for about 6-12 months before the PTH levels start to rise. You cannot have Stage II, or Stage III kidney failure and have secondary hyperparathyroidism. This does not happen. In fact, it is very rare to have Stage IV kidney failure and have secondary hyperparathyroidism. It is almost 100% true that you cannot have secondary hyperparathyroidism unless you have Stage V (5) kidney failure and are on dialysis. If you are not on dialysis, then you almost surely do not have secondary hyperparathyroidism. This mistake is made very commonly. Also remember, you cannot have secondary hyperparathyroidism if your calcium is not low normal or low.

Therefore, if you have 1) kidney failure of some form, 2) your parathyroid hormone (PTH) is high, 3) your calcium is 10.0 mg/dl or higher, and 4) you have not been on dialysis for 1 year or more, then you have PRIMARY hyperparathyroidism and you do not have secondary hyperparathyroidism. Why is this important? Because it is very likely that the parathyroid tumor is what is killing your kidney!  Are you listening? We see this mistake made every single day. If your PTH is high and your doctors say you have secondary hyperparathyroidism and you are not on dialysis, then you almost for sure have PRIMARY hyperparathyroidism and you need to get your parathyroid TUMOR out of your neck because it is killing your kidneys.  PLEASE read this again.  This page will save at least 100 patient's lives every day. Parathyroid tumors kill kidneys (over a number of years), and if you have high PTH levels and you are not on dialysis, then it is very likely the parathyroid tumor is either directly responsible for the kidney failure, or it is making it much worse. You cannot have secondary hyperparathyroidism unless your calcium is very low, and you cannot have secondary hyperparathyroidism if your GFR is over 25.

Our Vitamin-D-Pro app was designed exactly for this purpose. It will absolutely tell you if you have secondary hyperparathyroidism or primary hyperparathyroidism.  Get it in the Apple store, or get it in the Google Play store. You need to have your blood test results--just plug them into the app and the computer will tell you primary vs. secondary hyperparathyroidism and tell you if you need to take vitamin D or if you need to have an operation to remove the tumor from your neck.  We made this app because MOST doctors can't get this right! It costs $1.99

Why did the secondary hyperparathyroidism occur?

The common thread for all of these conditions is that the intestines do not absorb enough calcium because there is either 1) a problem with the intestine wall so that the calcium cannot get from inside the intestines through the intestine wall and into the blood, or 2) not enough vitamin D to help transport the calcium through the intestine wall. Remember, the only thing vitamin D does in the human body (with a few exceptions) is to transport calcium from our food into our blood through the intestine wall. Vitamin D is a transport molecule for calcium. Thus if a person has a very low vitamin D level, they will have problems absorbing calcium that they eat into their blood. This is why most milk has vitamin D added to it, and why almost all calcium pills you can buy have vitamin D in them. To understand why kidney failure causes secondary hyperparathyroidism you have to remember that the active form of vitamin D is produced by the kidney! Thus if the kidneys have failed, the patient cannot activate the vitamin D and therefore they cannot absorb calcium in their diet.

Remember, to have secondary hyperparathyroidism, you MUST have a low blood calcium--which is what caused the parathyroid glands to go crazy.  If your doctor says that you have high blood calcium because you have a low vitamin D level, he/she is wrong. It is impossible for low vitamin D to cause a high blood calcium. Vitamin D is required to absorb calcium from our diets through our intestine wall, and if the vitamin D is low then you can't absorb enough calcium and your blood calcium goes LOW. HOWEVER, this is RARE, and can ONLY occur in the diseases above. And, you are VERY SICK from these other diseases, so it isn't a surprise.

Secondary Hyperparathyroidism: How Many Parathyroid Glands are Bad?

Since secondary hyperparathyroidism is caused by some external force acting on the parathyroid glands (almost always this is low blood calcium), then all four of the parathyroid glands are exposed to this same LOW blood calcium level and thus all four glands go crazy and get big and juicy. When we operate on people with secondary hyperparathyroidism we find FOUR bad glands, and zero good glands, because they all were exposed to the bad situation of low calcium so they are trying very hard to get the blood calcium higher (remember, that's what parathyroid glands do--they control the blood calcium).

Patients with primary hyperparathyroidism have the disease because they grew a tumor on one (or two) of their parathyroid glands. Patients with primary hyperparathyroidism almost never have 4 bad glands (see photos of parathyroid tumors we took out of people--it isn't gross!).

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