When too much parathyroid hormone is produced by an overactive parathyroid gland. This is called hyperparathyroidism.
- HYPERPARATHYROIDISM (hyper-parathyroid-ism)
the condition of too much parathyroid gland activity
- hyper = too much
- parathyroid = parathyroid gland
- ism = a disease or condition
- "There is no other disease that is so easily cured which has such a tremendous impact on a patient's health and their quality of life"
Hyperparathyroidism occurs when one (or more) of the four parathyroid glands grows into a tumor and behaves inappropriately by constantly making excess parathyroid hormone. This award-winning video explains hyperparathyroidism in 5 minutes. You will see one of the parathyroid glands grow into a tumor and make too much parathyroid hormone which goes to the bones and removes calcium from the bones. This tumor has lost its control mechanism and makes large amounts of parathyroid hormone. Thus, even when the blood calcium level is high--when the parathyroids should not be making any hormone at all--one of the glands keeps making hormone. Remember as you read about hyperparathyroidism on these pages, it is a hormone problem secreted by a benign parathyroid tumor. It is not a cancer problem, however it can increase the occurrence of other cancers. This animation will show you how the tumor in your neck causes calcium to leach out of the bones and clog your arteries and kidneys, and make you feel bad.
Watch a video at https://www.youtube.com/embed/sD9st1ZPFrQ
Sometimes hyperparathyroidism makes people miserable within the first year or two of having high blood calcium (see our page on symptoms of hyperparathyroidism). Other times it can go 10 years without causing too much problems other than fatigue, bad memory, kidney stones, and osteoporosis. But make no mistake about it, hyperparathyroidism kills people--it just takes 20 or so years to do so.
Hyperparathyroidism: What Causes Excess Parathyroid Hormone Production?
The most common cause of excess hormone production (hyperparathyroidism) is the development of a benign tumor in one of the parathyroid glands. This enlargement of one parathyroid gland is called a parathyroid adenoma which accounts for about 70 percent of all patients with primary hyperparathyroidism (the other 30% will have more than one bad gland, see chart below). This out of control parathyroid gland is essentially never cancerous (virtually 100% of them are benign tumors), however, it slowly causes damage to the body because it induces an abnormally high level of calcium in the blood which can slowly destroy a number of tissues. Parathyroid adenomas typically are much bigger than the normal "grain-of-rice" parathyroid and will frequently be about the size of an olive or grape. Thus, the typical patient with hyperparathyroidism will be cured of the disease when this "olive" size tumor is removed. Up to 30% will have more than one tumor, so your surgeon should test to make sure the others are all good. People live just fine with less than four normal parathyroid glands that will be about the size of a grain of rice. The picture to the left is a picture of a typical parathyroid adenoma (parathyroid tumor) that causes hyperparathyroidism. This is a very average tumor size, shape, and color. Most people with hyperparathyroidism will have a tumor in their neck about this size, some will have two. Remember, the normal parathyroid gland is about the size of a grain of rice... but one cell inside this normal parathyroid gland went out of control and started reproducing itself until a large tumor developed. This tumor will almost always continue to grow until it is removed. As it grows, it makes more hormone and will make you feel worse. This tumor is constantly making parathyroid hormone which is what takes the calcium out of your bones and makes the calcium in your blood too high. (We have an entire page of photographs of parathyroid tumors so you can see what these little boogers look like!).
Where did this parathyroid tumor come from?
This is a great question, and the answer is quite simple... In most cases we don't know WHY parathyroid tumors form. But this is HOW a parathyroid tumor forms: The normal parathyroid gland is made up of about 80,000 very small parathyroid cells. Each one is exposed to lots of blood flow and they all measure the calcium in the blood. When the calcium is low, they make parathyroid hormone (abbreviated PTH). When the calcium is high, they stop making hormone. They normally turn on and off hundreds of times per day. All of these cells act independent of the other. Occasionally, one of these cells will go nuts and start reproducing itself... a million or more times. The crazy "mother" cell divides into two, then does it again, and again, and again; many times a day. Over a period of several years a tumor develops. This tumor mass (seen in the photos on this site) is made up of millions of cells all of which are sisters from one crazy "mother" cell. Each of these "daughter" cells inherited the craziness of the mom, and they don't pay attention to the calcium level in the blood. They are out of control, making PTH whenever they want, in as much concentration as they want. When you look at all the pictures of the parathyroid tumors on this web site, you will see a small (rice-size) yellow NORMAL gland with a dark-red tumor growing out of it. The tumor mass is composed of millions of crazy daughter cells from one mother cell that went nuts. If you have surgery at the Norman Parathyroid Center, you will get a photo of your tumor, and you can almost always see the normal gland from which the tumor arose.
This graph shows the blood parathyroid hormone levels in 18,000 patients operated on at the Norman Parathyroid Center for primary hyperparathyroidism. Normal blood levels of parathyroid hormone vary according to the lab that measures the hormone, but most labs have a normal level between 15 and 65 pg/ml. Each of the patients represented here had a parathyroid tumor removed from their neck. As you can see, most (but not all!) of them have parathyroid hormone levels that are above normal (above 65).
Note that most patients with primary hyperparathyroidism (due to a benign tumor in their neck) have PTH levels ranging from 50 to 150. When patients have PTH levels above 180 it is because their tumor is very old (usually this means over 15 years old) and the tumor is composed of MANY cells. If your PTH level is over 180, then some doctor somewhere was asleep at the wheel for at least 10 years. This should not be allowed to happen, and the amount of destruction to your body is generally worse. Also note that about 17% of our last 30,000 patients that have a parathyroid tumor in their neck will have PTH levels that are in the "normal range". Let us say that again... about 17% of patients with hyperparathyroidism will have high calcium levels and NORMAL PTH levels every time the PTH is checked. Realize that this is still hyperparathyroidism and they still have a parathyroid tumor in their neck... We say their PTH level is "inappropriately normal". In other words, it still shows that there is a tumor full of crazy, out of control cells because if they were normal parathyroid cells they would sense the high calcium and they would shut down. If your calcium is high, and your PTH is not near zero (consistently 25 or below), then you almost certainly have a parathyroid tumor. GET IT OUT! Importantly, about 50% of people with a parathyroid tumor will have PTH levels that are high sometimes and normal sometimes. You do NOT need to have high PTH levels to have a parathyroid tumor. Please, teach your doctors this! High calcium and PTH levels that are not low means a parathyroid tumor is present in virtually every case. The upper limit of normal calcium is discussed on (see our page on other pages of this website), but remember, if you are over 40 years of age, your calcuim levels should be 10.0 mg/dl or below (should be in the 9's). (For our European and Canadian friends, your calcium should be below 2.5 mmol/l)
One final note about this graph which shows Parathyroid Hormone (PTH) levels in patients with primary hyperparathyroidism. This graph is different from the graph at the bottom of our diagnosis page which shows CALCIUM levels in patients with primary hyperparathyroidism. These graphs have the same shape and thus you could confuse them... but one looks at the hormone levels in the blood, and the other looks at the calcium level in the blood. These two graphs are central to the diagnosis of hyperparathyroidism.
About 30% of people with Hyperparathyroidism will have more than one parathyrroid tumor!
Approximately 25% of patients with primary hyperparathyroidism will have two parathyroid adenomas while having two normal glands. This is one of the reasons why parathyroid surgery is tricky--because some people will have one tumor while others will have more than one. This is why the most experienced parathyroid surgeons will examine all four parathyroid glands during the operation--so a second tumor is not left behind. Surgeons who do lots of parathyroid surgery will not just take one parathyroid tumor out and quit the operation. Instead they will spend the necessary time to make sure there isn't a second tumor (watch our surgery video to see Dr Norman find a second tumor). The most common reason that people have an unsuccessful parathyroid operation is because the surgeon couldn't find the tumor. The second most common cause for people to have a failed parathyroid operation is because they had two tumors and the surgeon removed only one. As you choose your surgeon, ask hard questions and be careful of surgeons who claim to be experts, but will only look at one gland and measure hormone levels. This does not take any expertise--any surgery intern can take out a tumor shown on a scan and not check the others.
Around 5% of all patients with primary hyperparathyroidism will have an enlargement of all four parathyroid glands, a term called parathyroid hyperplasia. In this instance, all of the parathyroid glands become enlarged and produce too much parathyroid hormone. In most cases, we do not know the cause of the hyperplasia, just as we do not know the cause of the adenoma. Some patients with hyperplasia have a genetic condition that causes parathyroid disease, such as Multiple Endocrine Neoplasia (MEN). Note, though, that most patients with hyperplasia will not have an MEN syndrome! Again: if you have hyperplasia, you likely do not have MEN. Interestingly, patients with just "mildly" elevated calcium levels are more likely to have hyperplasia, rather than parathyroid adenomas. Patients with hyperplasia will need to have a "subtotal parathyroidectomy", during which the largest glands are removed, leaving just a piece of one parathyroid gland. The recovery after this procedure is the same as if one parathyroid gland was removed. You only need one parathyroid gland (or part of one) to maintain calcium levels.
Does Too Much Parathyroid Hormone and Calcium Cause Symptoms?
Hyperparathyroidism causes symptoms in almost everybody, but sometimes they are quite subtle. We have put all of this information on a different page: Click here to learn about Symptoms and dangers of Parathyroid Disease. It is important for you to understand these few facts about blood calcium:
- It is almost never normal to have a high calcium level in your blood. Said differently, it is almost never for adults over 40 to have persistent calcium levels of 10.1 or higher. See our page on "Normal Levels According to Age", since many labs will show the upper limit of normal for blood calcium up to 10.5 mg/dl--which is for teenagers and not adults over 30.
- Almost all patients with high calcium in the blood have one or two bad parathyroid glands that is causing it. Your doctor may look for other causes... but the overwhelming odds are that you will end up with parathyroid disease. We have an entire page discussing the other even more rare causes of high blood calcium on this web site, but don't spend too much time there reading about things you don't have. Persistent calcium levels over 10.1 (in an adult) is almost always a parathyroid tumor.
- The bad parathyroid gland(s) is a tumor. It is a benign tumor (not cancer), but it is a tumor.
- Most parathyroid tumors are between the size of peanut and a grape. Rarely they can be as big as a golf ball... or bigger. However, the size of the tumor doesn't matter too much, just how much hormone it produces and how much calcium it is taking out of your bones. We have photos of these tumors on another page. If you have a big tumor, you are the loser not the winner. These are slow growing tumors and if you have a large one, it usually means your doctors have missed it for years.
- An expert in parathyroid surgery can fix this problem in 20 minutes or less. So if your surgeon says that it will take 2 or 3 hours in the operating room, you may want to find an expert surgeon. If he says it may take about 1.5 hours, then you may want to ask if it might take longer--you can be assured that he will say "yes, it could take as long as 4 hours or more". As you will read on this site and every other web site (or book) ever printed on the topic, picking your surgeon is the most important step, since the outcomes (cure rates and complications) are directly related to surgeon experience. There is no other area of the body that has such variable anatomy.
- Removing the bad parathyroid tumor will cure the hyperparathyroidism and will make the calcium level go back to normal within hours. Of course, this is only the case if the patient only has one tumor. We really should say "removing all of the tumors" will cure the patient, remembering of course, that you CANNOT take all four parathyroid glands out!
- It is very rare for people to get parathyroid disease (hyperparathyroidism) twice--if the surgeon did the operation correctly the first time, analyzed all four parathyroid glands, and carefully removed the tumor(s) by the root.. Said differently, surgery cures this disease, it is not a treatment for the disease. You should never get hyperparathyroidism again if you have a surgeon who cures you the first time. If your surgeon can't tell you that his/her cure rate for you will be 97% or higher, then go somewhere else. If he/she says the cure rate will be 90% or better and he/she is only going to look at the one parathyroid gland that shows on the scan, then know this is a fib. This isn't possible. Our office is full of people who were told this. If 30% of people have more than one tumor, then how can any surgeon know ahead of time that he/she has >90% cure rate if they only look at one parathyroid gland and stop the operation?
- Removing the parathyroid tumor will change the patient's life. It often will make you feel 10 years younger, and literally, change your life. Read about symptoms. Read testimonials from about 2,000 patients.
- Removing the parathyroid tumor will make you live longer (statistically). From a statistical standpoint, patients with hyperparathyroidism die an average of 5-6 years sooner than expected. This is because the incidence of several cancers is increased by 1.8 to 3-fold (breast, colon, kidney, and prostate), the incidence of high blood pressure is 5.5 times higher, stroke is 4 times higher, heart disease is 2.5 times higher, atrial fibrillation (A-Fib) is 8 times higher. This is all explained in more detail on our Symptoms page, including footnotes to medical journals. Thus, parathyroid tumors are benign (not cancerous), but they slowly destroy your body, eventually making you feel miserable, and increasing your chance of several cancers dramatically. Do NOT "watch" your high calcium levels!
How Many People Get Parathyroid Disease? (Hyperparathyroidism)?
The incidence of parathyroid disease (hyperparathyroidism) is 1 in 80 people in their lifetime (more than 1% of people). This rate is much higher in women over 50 where the rate is 1 in 50 or so. If you want to see how common this is, take a look at the map of people we have operated on and you will see that we operated on a neighbor of yours. All of you will know somebody with hyperparathyroidism. Unfortunately, about 70% of patients with hyperparathyroidism do not know they have it... they have high calcium levels but their doctors don't know what this means and so the high calcium is ignored. Often, when something bad happens (kidney stones, bad osteoporosis, severe depression), then the doctors pay attention to the high calcium. Hyperparathyroidism occurs in women more often than men (almost exactly 75% women, 25% men), and the average age is about 59 years old--but people of any age can get it. Young people do get parathyroid disease, but this is rare. We have an entire page dedicated to this topic--Read about Who Gets It?
How Many Parathyroid Glands are Bad?
Since everybody has 4 parathyroid glands, we could potentially get tumors in all four glands. This is almost impossible, however, because the person would be so sick that it would have been figured out sooner. Almost all people with hyperparathyroidism have just one or two parathyroid tumors. In January, 2010 we published data on 10,000 patients that we operated on and cured for hyperparathyroidism to show average calcium and PTH levels, and to show that a lot of people with hyperparathyroidism don't have high PTH levels. In 2012 we published another article on 16,500 patients in the Journal of the American College of Surgeons showing that the only way to make sure a patient is cured is if the surgeon looks at all four parathyroid glands. Just taking out the one tumor shown on a scan will result in 20-25% of people needing a second operation! Here is an update from January 2014 looking at our last 23,000 parathyroid operations, and the number of bad parathyroid glands they had:
|Percentage||Number of bad parathyroid glands|
|70%||one enlarged, overactive gland (termed a single adenoma)|
|25%||two or three large glands (termed double adenomas)|
|5%||four enlarged, overactive glands (termed four-gland hyperplasia)|
|<<<1 %||cancer of the parathyroid (extremely rare). Do NOT worry about parathyroid cancer!|
Importantly, 25% to 30% of people with hyperparathyroidism have more than one parathyroid tumor and there is no way of telling who this is before the operation. In fact, there is no way to know which patient has one tumor and which has two without looking at each gland during the operation by looking and testing each of the 4 glands. Be careful of any doctor that says to you "the scan shows that you only have one parathyroid tumor" because scans are wrong more often than they are right. Nobody can tell you before the operation that you have just one tumor. We perform 4,300 parathyroid operations per year and we look at all four glands in virtually all of our operations because you cannot tell who has one tumor and who has more than one without actually looking at them. Watch the 13 minute video of Dr Norman performing this operation---the scans very clearly show this patient has ONE parathyroid tumor, but when Dr Norman looks at all four glands he finds TWO tumors. Also, you will know instantly that your doctor is not an expert if they tell you before the operation that you are one of the 30% of people that have more than one tumor. There is no way to know this before the operation, and there is no way to know this in the operating room without actually checking all four glands.
Having all four parathyroid glands enlarged (parathyroid hyperplasia) in uncommon. There are several factors that make you more likely to have hyperplasia, but note that most patients with hyperplasia will not have any of these! Factors associated with parathyroid hyperplasia: 1) Long-term lithium therapy 2) Kidney failure, usually on dialysis (called secondary hyperparathyroidism), or 3) a genetic condition like multiple endocrine neoplasia (MEN) syndrome that causes multiple endocrine tumors in families. And then some patients with classic primary hyperparathyroidism who do not have any of these conditions will have hyperplasia. It just happens. It is treated the same way as all hyperparathyroidism: by removing the problem glands.
Essentially all patients with hyperparathyroidism will benefit from having surgery. The high blood calcium is far more dangerous than high cholesterol and it is a sign that your body is being eaten away from the inside. This is a disease that makes most people feel miserable while it destroys their body. The only choice you really need to make is to choose your surgeon. Then let the surgeon worry about 1 bad gland, 2 bad glands, or 4 bad glands. The operation is the same... same anesthesia, same incision, same 1.5 hours in the recovery room... everything is the same.
How the One Bad Parathyroid (the Adenoma) Affects the Other Three.
To teach how the parathyroid glands respond normally to calcium levels and how the parathyroid glands are supposed to work, we will use your home's heating system in the winter as an example.
We all have a heater in our homes that is controlled by a thermostat. When we set the thermostat on 70 degrees, it is this temperature that the thermostat will constantly monitor and turn on the heater when the temperature drops. If the temperature drops to about 68 degrees, the thermostat detects it and turns on the heater. The heater warms the room until the thermostat recognizes the increase in temperature, and when it reaches 72 degrees the thermostat turns OFF the heater. In reality, the heater in your home will turn on and off about 50 times per day. The temperature in the room will vary some, from a little above 70 degrees to a little below, but we don't notice it when the thermostat is working normally.
All of our parathyroid glands have a built in "thermostat" (all endocrine glands do!). The thermostat in the parathyroid glands is very sensitive to calcium levels in the blood. The normal 'setting' for the thermostat in the parathyroid glands is for a calcium level between 8.5 and 10.2. Calcium is not just responsible for our bone strength, but it is the source of electrical energy in our nervous system and muscles, thus humans want this element controlled very, very well. Calcium is the ONLY element in the body that has its own control system!
Normal parathyroid glands constantly monitor the calcium in the blood. When the calcium levels drop, the parathyroid glands turn on... and make parathyroid hormone (PTH). The PTH acts directly on the bones within minutes and takes some calcium out of the bones (we use the bones as a storage system for calcium). Now the level of calcium in the blood will increase a little--and the parathyroid glands recognize this and turn themselves off. Just like the thermostat that turned on when the temperature got low, the normal parathyroid glands turned on when the calcium got low. And, just like the thermostat that turned off when the temperature in the room got warm, the normal parathyroid glands turn off and stop making PTH when the calcium rose a little bit. This is why your calcium will vary every time your doctor measures it... it's always a little different, but it is always supposed to be in the normal range.
What happens in patients with Hyperparathyroidism? Well that is now a simple answer. One of the parathyroid glands developed a tumor. That tumor (an overgrowth of cells) will be about the size of an olive (typically) and it will do what it likes to do...MAKE HORMONE! So, you have this one big, bad parathyroid gland that is making hormone 24 hours per day... its thermostat is broken! It does NOT respond to the high calcium levels and turn off...instead it is stuck in the "on position", and constantly makes parathyroid hormone (PTH). Well, this PTH keeps working on your bones, taking calcium out of the bones and putting it in your blood. The bones become thin (osteoporosis), and the calcium in the blood is elevated out of the normal range. We get nervous system symptoms due to the brain not liking the high calcium levels (depression, tiredness, mean-ness, lack of energy, problems sleeping, etc). We can also get kidney stones and other problems due to all the extra calcium floating around.
What happens to the NORMAL parathyroids when you have one bad parathyroid gland? Well that answer is now clear also. In the overwhelming majority of people with hyperparathyroidism, they will have one bad gland and 3 normal glands. The one bad gland is big and producing PTH all day long...making the calcium go high. Well, the three normal glands will still have a normal thermostat. They will recognize the high calcium and shut down their hormone making apparatus. Thus they become dormant and go to sleep. Since most people with parathyroid disease don't get diagnosed until they have had it for years--the normal parathyroid glands will have been dormant for years by the time the surgeon operates to take out the bad one. This is why experienced surgeons will provide their patients with calcium pills to take for the first few weeks after parathyroid surgery. It will take a week or two for the normal parathyroid glands to wake up and begin to regulate the calcium normally (to get their thermostats working properly). Without taking lots of calcium during that time, your calcium can drop too low and you will get sick (have problems with your nervous system and brain, like feel bad, feel 'foggy' and confused, fell anxious and 'doomed', feel out of control; get tingling in your hands and fingers and around your mouth, get cramps in your hands and feet). These are all symptoms of LOW calcium, and they can happen to patients after a successful parathyroid operation. The symptoms are temporary, and will go away after the nervous system gets used to the new 'normal' calcium levels. It may take 2 - 5 days, but these symptoms will always go away, and they are always treated the same way--take more calcium! If you get these symptoms after a parathyroid surgery--it means the surgery was successful, but your body doesn't like the new calcium levels yet and wants more calcium. You MUST give it more calcium if you have these symptoms. (Please understand, 94% of people will NOT have these symptoms as long as they take their calcium pills after the surgery)... and the ones that do have symptoms of low calcium simply have to take more calcium. (Note, these statistics come from our recent publication where we studied this in 6000 consecutive patients who went home within 1.5 hours of their operation. Of course, this is why all our patients get our home phone and cell phone numbers).
Do I Really Need to Get this Parathyroid Tumor Removed?
The simple answer is this: yes. Having high calcium in your blood is much more dangerous than having high cholesterol. Having high blood calcium is more deadly than having thyroid cancer. In fact, having a parathyroid tumor caries the same risk of early death as having diabetes. The high calcium increases your risk of stroke, heart attack, and heart failure due to the aggressive buildup of calcium in the arteries. The high calcium increases the risk of developing several cancers by 2 to 3 times, including breast cancer, colon cancer, kidney cancer and prostate cancer. Of course, the high calcium came from the bones, so you will get osteoporosis and even severe osteoporosis that cannot be treated with drugs--and your bones will fracture. Of course, the high calcium makes you feel tired, increases your blood pressure, makes you fatigued and takes away the joy of life. Read more about the symptoms of hyperparathyroidism on our Symptoms page.
The good news is that hyperparathyroidism is a disease that is easily cured. We don't "treat" hyperparathyroidism like you would "treat" diabetes. Parathyroid problems are cured by simply taking out the parathyroid tumor that is causing all the troubles. Once it is out, the disease is cured and the risk of cancers, stroke, heart attacks (etc) associated with untreated hyperparathyroidism will decrease. Get the tumor out and put this behind you! Feel better, live longer--get the darn tumor out of your neck!